Poppy, accompanied by her troublesome son Junior, his skunk friend, and Uncle Ereth the porcupine, responds to a summons to return to her ancestral home, Gray House, to save the mice there from destruction by a bulldozer.

The ordinary interactions and everyday routines of the Watsons, an African American family living in Flint, Michigan, are drastically changed after they go to visit Grandma in Alabama in the summer of 1963.